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Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update

Podlesny D, Durdevic M, Paramsothy S, et al

[83] A largely unappreciated secondary function of SOD1 enzymatic activity is the modulation of signal transduction pathways (Figure 7)

Lack of clinical evidence: Although there is encouraging preclinical research indicating the neuroprotective potential of phytochemicals in TBIs, the absence of comprehensive clinical data hinders the ability to substantiate their effectiveness and safety in human patients